AA amyloidosis in a polyarteritis nodosa patient treated with tocilizumab

Alojzija HočevarDepartment of Rheumatology, University Medical Centre Ljubljana LjubljanaSloveniaCorrespondence[email protected]

Boris LestanDepartment of Rheumatology, University Medical Centre Ljubljana LjubljanaSlovenia

Snežna Sodin ŠemrlDepartment of Rheumatology, University Medical Centre Ljubljana LjubljanaSlovenia;Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska KoperSlovenia

Katja LakotaDepartment of Rheumatology, University Medical Centre Ljubljana LjubljanaSlovenia

Nika KojcFaculty of Medicine, Institute of Pathology, University of Ljubljana LjubljanaSlovenia

Nataša PotočnikDepartment of Rheumatology, University Medical Centre Ljubljana LjubljanaSlovenia

Matija TomšičDepartment of Rheumatology, University Medical Centre Ljubljana LjubljanaSlovenia;Faculty of Medicine, University of Ljubljana LjubljanaSlovenia

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Abstract

Amyloid A (AA) (secondary) amyloidosis represents a severe complication of chronic inflammatory diseases. Since pathogenic mechanisms point to the central role of interleukin 6 (IL-6) in the process of amyloid AA generation, IL-6 blockade seems an attractive therapeutic option. We report a case of a patient with polyarteritis nodosa complicated by AA amyloidosis treated with tocilizumab.

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AA amyloidosis in a polyarteritis nodosa patient treated with tocilizumab

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AA amyloidosis in a polyarteritis nodosa patient treated with tocilizumab

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