Plasmacytoma of the nasal cavity with lambda III amyloid deposition

Oron Eilam Departments of The Richard L. Roudebush Veterans Affairs Medical Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA

Juris J. Liepnieks Departments of The Richard L. Roudebush Veterans Affairs Medical Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA

Edward Weisberger Departments of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA; Departments of The Richard L. Roudebush Veterans Affairs Medical Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA

Merrill D. Benson Departments of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA; Departments of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA; Departments of The Richard L. Roudebush Veterans Affairs Medical Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA

Abstract

A patient presented with a large nasal plasmacytoma that involved the palate, ethmoid and maxillary sinuses and contained deposits of amyloid. Immunoglobulin (AL) amyloid was found in the tumor. Amyloid fibrils extracted from the resected tumor were found to contain lambda light chain protein. Complete sequence analysis identified the protein as lambda III immunoglobulin light chain. Evaluation of the patient failed to reveal any sign of systemic amyloidosis and three years of follow-up has shown no evidence of recurrence.

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Plasmacytoma of the nasal cavity with lambda III amyloid deposition

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Plasmacytoma of the nasal cavity with lambda III amyloid deposition

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