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Abstract
Background: The aim of this study was to describe a method to measure ischaemia-induced alterations of the binding capacity of serum albumin to exogenous nickel.
Methods: We measured the levels of cardiac troponin I (cTnI), serum albumin, ischaemia-modified albumin (IMA) measured by a cobalt–albumin binding assay (CABA), and a nickel–albumin binding assay (NABA) in the following groups: myocardial infarction (n = 32) and non-ischaemic chest pain (n = 64).
Results: IMA, cTnI and NABA levels were higher in the myocardial infarction group. NABA presented a higher ability to discriminate myocardial ischaemia than CABA.
Conclusions: Patients with myocardial infarction have reduced nickel binding to human serum albumin, and NABA may have an important role as an early marker of myocardial ischaemia.
Acknowledgements
This study was supported by a grant from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil, process number 477843/2008-5). CNPq and FAPERGS provided fellowships.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.