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Abstract
The AKNA gene is part of the 9q32 susceptibility locus for cervical cancer. A single-nucleotide polymorphism at codon 1119 of AKNA, yields a biologically relevant amino acid change (R1119Q) at the DNA binding AT-hook motif. Genotype frequencies in 97 allele pairs were: R/R = 0.597, R/Q = 0.278, Q/Q = 0.123. Q/Q homozygosity was present in 8.33% of healthy controls, 16.67% of patients with cervical intraepithelial neoplasia and 75% of cervical cancer patients. These differences are highly significant for the presence of Q/Q in cervical cancer (p = 0.01, odds ratio 3.66, 95% confidence interval 1.35–9.94). Therefore, AKNA appears to be an important genetic factor associated with the risk cervical cancer.
Acknowledgements
We thank Dr Takahiro Nagase from Kasuza DNA Research Institute, Chiba, Japan, for the donation of the plasmid pBS00020, Dr Michael Pickard, Department of Biological Sciences, University of Alberta, Edmonton, Canada for donation of Pfu polymerase, Dr Guillermina López-Estrada from the General Hospital in Cuernavaca, for the histopathological diagnosis and M.S. Cinthya Diaz Benitez from Instituto Nacional de Salud Pública for her logistic help. The funds for this work were obtained from Instituto Nacional de Salud Pública, and by the Mexican government through a grant from SEP-CONACyT (46151), and a CONACyT fellowship to G.P. This work was submitted in partial fulfilment of the requirements for the DSc degree by G.P. at the Doctorado en Ciencias Biomédicas, Facultad de Medicina, Universidad Nacional Autónoma de México, no. 85525478.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.