Association of Stem Cell-Related Markers and Survival in Astrocytic Gliomas

Christel Herold-MendeDivision of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, GermanyCorrespondence[email protected]

Benito CamposDivision of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany

Franz-Simon CentnerDivision of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany

Christine DictusDivision of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany

Natalia BeckerDivision of Molecular Genetics, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany

Frauke DevensDivision of Molecular Genetics, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany

Carolin MoglerDepartment of General Pathology, University of Heidelberg, INF 220, 69120 Heidelberg, Germany

Jörg FelsbergDepartment of Neuropathology, University of Düsseldorf, 40225 Düsseldorf, Germany

Niels GrabeInstitute of Medical Biometry and Informatics, Hamamatsu Tissue Imaging and Analysis (TIGA) Center, University of Heidelberg, INF 305, 69120 Heidelberg, Germany

Guido ReifenbergerDepartment of Neuropathology, University of Düsseldorf, 40225 Düsseldorf, Germany

Peter LichterDivision of Molecular Genetics, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany

Andreas UnterbergDivision of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany

Justo Lorenzo Bermejo

Rezvan AhmadiDivision of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany

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Abstract

To study the clinical relevance of undifferentiated tumour cells in astrocytic gliomas we employed a large tumour tissue microarray (n = 283) with corresponding clinical data and analyzed the expression of Nestin and Sox-2, which mark undifferentiated stem- and progenitor cells in the normal brain.

Both markers were expressed abundantly and staining of nestin significantly increased with WHO grade. Further, nestin and Sox-2 immunoreactivity was significantly associated with tumour cell proliferation and nestin expression was independently associated with poor patient survival.

Our findings suggest that immature glioma cells are involved in tumour growth and tumour progression and significantly impact on patient prognosis.

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Association of Stem Cell-Related Markers and Survival in Astrocytic Gliomas

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Association of Stem Cell-Related Markers and Survival in Astrocytic Gliomas

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