Biomarkers of exposure to endogenous oxidative and aldehyde stress

Abstract

We observed an unexpectedly strong association of three different endogenous aldehydes and noted that the association could be explained by multiple reactions in which oxidative stress increased the formation of endogenous aldehydes and endogenous aldehydes increased oxidative stress. These interactions make it reasonable to assess multiple exposures to endogenous oxidative and aldehyde stress with less specific measures such as advanced glycation end-products or protein carbonyls.

Keywords::

• Colorectal cancer
• oxidative stress
• fructose
• endogenous aldehydes
• advanced glycation end-products (AGEs)
• protein carbonyls

Acknowledgments

We thank our participants for their contributions and Maria Cirocco and Heather White for the arrangements and collection of samples. We are greatly indebted to our colleagues Patrice D. Cani, Université catholique de Louvain, Brussels, Adria Giacca and Young-In Kim, University of Toronto, and David W. L. Ma, Department of Human Health and Nutritional Sciences, University of Guelph, for their kind support and help.

Declaration of interest

This work was supported by the St. Michael’s Hospital GI Division Research Funding Opportunity and the Cancer Research Society Inc.