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Research Article

Bacteremia and MR-proANP changes in mild community-acquired pneumonia

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Pages 637-641 | Received 18 May 2011, Accepted 01 Sep 2011, Published online: 21 Nov 2011
 

Abstract

Background: Mid-regional pro-atrial natriuretic peptide (MR-proANP) increases with severity in community-acquired pneumonia (CAP). We investigated whether changes of MR-proANP correlated to bacteremia.

Methods: 392 adult patients with CAP visiting emergency department from a prospective observational multicenter study.

Results: MR-proANP levels increased in patients with positive bacteremia (92.8 pmol/L vs. 84.3 pmol/L, p = 0.04). Performance of MR-proANP to detect bacteremia (0.60) was equivalent to CRP (0.59) but less accurate than PCT (0.69).

Conclusion: MR-ANP poorly predicts bacteremia in CAP patients.

Acknowledgments

We are indebted to Prof. Jean-Marc Treluyer, Dr Raphaël Serreau, Mélanie Anoussamy, Cécile Klochendler, Sandra Colas and the staff of the Clinical Research Department (Unité de Recherche Clinique, URC) Cochin-Paris Centre for their valuable technical and logistical support. We would like to thank Dr Romain Lecomte and Brahms Inc. for providing the Kryptor and corresponding reagents to obtain high quality dosages of PCT and ANP. We thank Dr Ohanessian Ekindjian who supervised dosage of biomarkers. We acknowledge Prof. Patrick Gerbeaux, Dr Julien Charpentier and Dr David Boutoille who reviewed each patient’s chart for the need of admission. This study was supported by the “Délégation Régionale de la Recherche Clinique,” APHP, Paris, France.

BIS Study Group: Cochin (Paris, France): J.C Allo, C. Barbotin, J.C Boulard, Y.E Claessens (P.I), A. Dabreteau, G. Der Sahakian, S. Esain, A. Gayet, C. Ginsburg (P.I), I. Iraqi-Chentouf, J Kansao, F. Lecomte, I. Mazariegos, O. Meyniard, F. Perruche, S. Pineau, R. Ranerison, K. Takun, C. Vartanian, L. Zarnitsky; Pitié-Salpétrière (Paris, France): R. Achkar, K. An, A. Arhan, M. Bendahou, J.F Benezet, P. Bonnet, A. Dardalon, N Delot-ElFakhri, S. Delerm, P. Hausfater (P.I), M.O Josse, J.S Marx, B. Madonna-Py, P. Ray, B. Riou, K. Saighi, B. Wellner; Hôpital Caremeau (Nîmes, France): P.G Claret, J.E de la Coussaye, T. Duclos, J. Flechet, P. Fournier, A. Gache, F. Hernandez, C. Hilaire, F. Jourdan, G. Kayser, S. Louvard, O. Onde, O. Paul, I. Rajeebally, P. Richard, H. Robert (P.I), J. Rousset, E. Vernes, P. Wagner-Kerdranvat; Hôpital Gabriel Montpied (Clermont-Ferrand, France): C. Billault, S. Boizat, A. Bommelaer, J.L Buisson, C. Carrias, M. Entwhistle, E. Jehle, A. Lenat, J. Liotier, T. Mathevon (P.I), C. Perrier, D. Pic, C. Pourrat, C. Rougier, J. Schmidt, F. Vaysse; Hôtel-Dieu (Nantes, France): I. Arnaudet, N. Asseray-Madani, P. Auneau, E. Batard (P.I), J. Dary, S. DiBernardo, D. ElKouri, C. Ferron, I. Gueffet, J. Jenvrin, V. Kuczer, P. Leconte, E. Legeard, C. Longo, J. Lorber, G. Potel, M.D Touze, D. Trewick, F. Vignaud, D. Yatim-Lequeret; Hôtel-Dieu (Paris, France): M. Baud, M.L Catinois, D. Cantin-Bertaux, F. Dumas, T. Jactat, L. Kachout, G. Kierzek (P.I), E. Hinglais, G. LeGuerrroue, J.L Pourriat, F. Trarieux, C. Wertheimer; Hôpital Européen Geoges Pompidou (Paris, France): M. Aitkaci, M.C Ballester, M Bouyx, T.H Cao, A. Davido, A. Gounaropoulos, A. Levy, O. Limaiem-Joumni, R. Masmoudi, C. Moreau, P. Meraud, A. Patzak (P.I), M.P Playe, M.P Sadier, N. Smbach, A. Severin, C. Vidal; Hôpital Bicêtre (Kremlin-Bicête, France): C. Choquet, J. Depret-Vassal, T. Gudj, S. Sarnel; Hôpital Bichat-Claude Bernard (Paris, France): M. Aliouane, E. Casalino (P.I), M. Dimitroff, LB. Rimaud, P. Werner; Hôpital Jean-Verdier (Bondy, France): J. Benkel, B. Bernot, C. Chassaignon, E. Debuc, G. Lenoir, D. Pateron (P.I), F. Pevirieri; Hôpital Lariboisière (Paris, France): C. Aparicio, J. Boni-Malka, J.P Courret, A. Debatisse, B. Galichon, S. Gallula, P. Gamand, S. Laribi, K. Mezaib, L. Pasgrimaud, F. Penit, P. Plaisance (P.I), F. Renai; Hôpital Louis Mourier (Colombes, France): A. Briere-Savard, P. Brun (P.I), B. Canderan, S. Hirsch, C. Lagarde, C. Leroy, F. Nikpay-Aslie, R. Sadat, F. Tessiere; Hôpital Sainte-Camille (Bry-sur-Marne, France): P. Collet, P. Hamlin, P. Lebrin, C. Loyer, G. Pinello, L.V.P Vong. Hôpital Beaujon (Clichy, France): P. Juvin, L. Lavagna-Perez (P.I).

We are indebted to Prof. Jean-Marc Treluyer, Dr Raphaël Serreau, Mélanie Anoussamy, Cécile Klochendler, Sandra Colas and the staff of the Clinical Research Department (Unité de Recherche Clinique, URC) Cochin-Paris Centre for their valuable technical and logistical support. We would like to thank Dr Romain Lecomte and Brahms Inc. for providing the Kryptor and corresponding reagents to obtain high quality dosages of PCT and ANP. We thank Dr Ohanessian Ekindjian who supervised dosage of biomarkers. We acknowledge Prof. Patrick Gerbeaux, Dr Julien Charpentier and Dr David Boutoille who reviewed each patient’s chart for the need of admission. This study was supported by the “Délégation Régionale de la Recherche Clinique,” APHP, Paris, France.

Declaration of interest

This study was supported by institutional grants by the French “Programme Hospitalier de Recherche Clinique,” 2003. Brahms Inc. freely provided the Kryptor and corresponding reagents to obtain high quality dosages of PCT and MR-proANP.

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