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Biomarkers Volume 17, 2012 - Issue 8
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Research Article

Changes and significance of serum angiopoietin-2 levels in patients with coronary heart disease

Xin Wang
,
Huijuan YongDepartment of Cardiology, Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides, Ministry of Health, Beijing, China
,
Lin MiDepartment of Cardiology, Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides, Ministry of Health, Beijing, China
,
Yun BaiDepartment of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
,
Lijun GuoDepartment of Cardiology, Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides, Ministry of Health, Beijing, China
,
Wei GaoDepartment of Cardiology, Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides, Ministry of Health, Beijing, China
,
Ming CuiDepartment of Cardiology, Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides, Ministry of Health, Beijing, ChinaCorrespondence[email protected] [email protected]
&
Yongzhen ZhangDepartment of Cardiology, Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides, Ministry of Health, Beijing, ChinaCorrespondence[email protected] [email protected]
 show all
Pages 745-749 | Received 15 Jul 2012, Accepted 31 Aug 2012, Published online: 29 Nov 2012
 
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Abstract

Coronary heart disease (CHD) is characterized by inflammatory process and endothelial dysfunction. To investigate angiopoietin-2 (Ang-2) profiles, we evaluated serum Ang-2 levels in different types of CHD in 166 subjects. Ang-2 was measured by enzyme-linked immunosorbent assay. Serum Ang-2 levels were significantly elevated in patients with CHD and gradually increased with advance of CHD. Ang-2 was positively correlated with Gensini scores and hs-CRP. Ang-2 might have potential implication in detecting and monitoring the progression of CHD.

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