Shedding of c-Met ectodomain correlates with c-Met expression in non-small cell lung cancer

Abstract

Objective: The aim of this study is to reveal the correlation of shedding and expression of c-Met in non-small cell lung cancer (NSCLC) patient.

Materials and methods: We measured soluble c-Met and c-Met level in a panel of pre-clinical models and 197 advanced Chinese NSCLC patients by enzyme-linked immunosorbent assay and immunohistochemistry, respectively.

Results: Shedding of soluble c-Met associates with total c-Met amount in pre-clinical models, and soluble c-Met correlates with both c-Met expression level and tumor size in human, high soluble c-Met predicts poorer outcome.

• c-Met
• lung cancer
• s-Met
• shedding

Acknowledgements

We thank Yan Yu and Hua Chao for their help in immunohistochemistry.