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Abstract
Objective: To evaluate soluble (s) ST2 as a biomarker of rejection, allograft vasculopathy and mortality after orthotopic heart transplantation (OHT).
Methods: sST2 concentrations were measured in 241 patients following OHT.
Results: Elevated sST2 was associated with cellular rejection (CR) ≥1R, with highest rates of CR in the 4th sST2 quartile (p = 0.003). No significant association between sST2 and antibody-mediated rejection or allograft vasculopathy was found. sST2 ≥30 ng/mL independently predicted death over 7-year follow-up (HR = 2.01; 95% CI 1.15–3.51; p = 0.01).
Conclusion: Concentrations of sST2 are associated with the presence of CR and predict long-term mortality following OHT.
Acknowledgements
The authors wish to thank Critical Diagnostics Inc for ST2 reagent support.