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Abstract
Objective: To identify methylated genes in serum with diagnostic potentials for early colorectal cancer (CRC).
Methods: Serum methylation levels of up to 12 genes were measured in two sets of serum samples with the second set from 26 stage I CRC patients and 26 age/gender-matched controls.
Results: Serum methylation levels of TAC1, SEPT9, and EYA4 were significant discriminants between stage I CRC and healthy controls. Combination of TAC1 and SEPT9 rendered 73.1% sensitivity with 92.3% specificity.
Conclusion: Serum methylation levels of TAC1. SEPT9 and EYA4 may be useful biomarkers for early detection of CRC though a validation study is necessary.
Acknowledgements
We thank Prof. Francis Seow-Choen for constructive suggestions at the initial stage of this study. We are also grateful to Ms SL Fong for technical assistance and Ms CT Loi for clinical data retrieval.