MicroRNA in Alzheimer’s disease: an exploratory study in brain, cerebrospinal fluid and plasma

Lynn M. BekrisDepartment of Geriatric (GRECC), Research, Education, and Clinical Centers, VA Puget Sound Health Care System Seattle, WAUSA;Department of Medicine, University of Washington Seattle, WAUSACorrespondence[email protected]

Franziska LutzDepartment of Geriatric (GRECC), Research, Education, and Clinical Centers, VA Puget Sound Health Care System Seattle, WAUSA;Department of Medicine, University of Washington Seattle, WAUSA

Thomas J. MontineDepartment of Pathology, University of Washington Seattle, WAUSA

Chang En YuDepartment of Geriatric (GRECC), Research, Education, and Clinical Centers, VA Puget Sound Health Care System Seattle, WAUSA;Department of Medicine, University of Washington Seattle, WAUSA

Debby TsuangDepartment of Geriatric (GRECC), Research, Education, and Clinical Centers, VA Puget Sound Health Care System Seattle, WAUSA;Department of Mental Illness (MIRECC), Research, Education, and Clinical Centers, VA Puget Sound Health Care System Seattle, WAUSA;Department of Psychiatry and Behavioral Sciences, University of Washington Seattle, WAUSA

Elaine R. PeskindDepartment of Mental Illness (MIRECC), Research, Education, and Clinical Centers, VA Puget Sound Health Care System Seattle, WAUSA;Department of Psychiatry and Behavioral Sciences, University of Washington Seattle, WAUSA

James B. LeverenzDepartment of Geriatric (GRECC), Research, Education, and Clinical Centers, VA Puget Sound Health Care System Seattle, WAUSA;Department of Mental Illness (MIRECC), Research, Education, and Clinical Centers, VA Puget Sound Health Care System Seattle, WAUSA;Department of Psychiatry and Behavioral Sciences, University of Washington Seattle, WAUSA;Department of Parkinson’s Disease (PADRECC), Research, Education, and Clinical Centers, VA Puget Sound Health Care System Seattle, WAUSA;Department of Neurology, University of Washington Seattle, WAUSA

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Abstract

MicroRNA (miRNA) may be potential biomarkers of Alzheimer’s disease (AD). The objective of this investigation was to demonstrate that miRNAs in human brain or biofluids are differentially expressed according to disease status, tissue type, neuritic plaque score or Braak stage. Post-mortem brain (PMB) miRNA were profiled using arrays and validated using quantitative RT-PCR (qRT-PCR). Five qRT-PCR-validated miRNAs were measured in an independent sample of PMB, cerebrospinal fluid and plasma from the same subjects. Plasma miR-15a was found to be associated with plaque score in the independent sample. In conclusion, miRNA present in human biofluids may offer utility as biomarkers of AD.

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MicroRNA in Alzheimer’s disease: an exploratory study in brain, cerebrospinal fluid and plasma

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MicroRNA in Alzheimer’s disease: an exploratory study in brain, cerebrospinal fluid and plasma

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