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Abstract
Objective: To investigate correlation of serum autotaxin and disease severity in biliary atresia (BA).
Methods: Eighty postoperative BA patients and 15 controls were recruited. Serum autotaxin levels were determined by enzyme-linked immunosorbent assay.
Results: BA patients had greater serum autotaxin and liver stiffness than controls. Serum autotaxin and liver stiffness were markedly elevated in BA patients with jaundice compared to those without jaundice. Furthermore, serum autotaxin was correlated with liver stiffness and biochemical parameters in BA.
Conclusions: Elevated serum autotaxin was correlated with hepatic dysfunction in BA. Accordingly, serum autotaxin is a promising biomarker reflecting the severity in BA.
Acknowledgements
The authors thank Research Core Facility of the Department of Biochemistry and Chulalongkorn Medical Research Center (ChulaMRC) for kindly providing facilities.
Declaration of interest
This study has been facilitated by the Thailand Research Fund. The authors report no conflicts of interest. Wanvisa Udomsinprasert has been supported by the 100th Anniversary Chulalongkorn University Fund for Doctoral Scholarship.