Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part 2. Biomarkers of exposure

Abstract

A randomized, multi-center study of adult cigarette smokers switched to tobacco-heating cigarettes, snus or ultra-low machine yield tobacco-burning cigarettes (50/group) was conducted, and subjects’ experience with the products was followed for 24 weeks. Differences in biomarkers of tobacco exposure between smokers and never smokers at baseline and among groups relative to each other and over time were assessed. Results indicated reduced exposure to many potentially harmful constituents found in cigarette smoke following product switching. Findings support differences in exposure from the use of various tobacco products and are relevant to the understanding of a risk continuum among tobacco products.

Trial registration: ClinicalTrials.gov identifier: NCT02061917.

• Mouth level exposure
• multi-center randomized study
• risk continuum
• tobacco and tobacco smoke constituents
• yield-in-use

Acknowledgements

The authors gratefully acknowledge Betsy Bombick, Gary Byrd, Summer Hanna, David Heavner, Tao Jin, George Krautter, Paul Nelson, Elaine Round, Thomas Steichen, and Weiying Yan.

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Declaration of interest

All authors are current employees of RAI Services Company or R.J. Reynolds Tobacco Company.

Supplementary material available online

Supplementary Tables 1-4