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Abstract
Objective: To identify the early changes of serum neuroglobin and Nogo-A concentrations and the relations to traumatic brain injury (TBI) severity and prognosis.
Methods: Serum samples were obtained and analyzed from 34 patients with TBI within the first 96 h after injury. Comparative analysis combined with Glasgow Coma Scale (GCS) scores and the 6-month prognosis of these patients was performed.
Results: Significant correlations were found between peak serum neuroglobin and Nogo-A concentrations and a patient’s GCS score on admission (p < 0.001). The mean peak serum neuroglobin and Nogo-A concentrations were both significantly higher in patients with an unfavorable outcome at 6 months after injury (p < 0.05).
Conclusions: Serum neuroglobin and Nogo-A levels could be suggested as biomarkers for predicting TBI severity and prognosis.
Trial registration: ClinicalTrials.gov identifier: NCT02229643.
Acknowledgments
We would like to acknowledge the assistance of Jun Ding and Fang Yuan in the statistical analysis of our data.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
Funding for this study was provided by National Nature Science Foundation of China (81271383), and Shanghai Jiao Tong University Affiliated Sixth People's Hospital foundation (1462 and 1583).