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Abstract
Endothelial microparticle (EMP) is a biomarker for endothelial dysfunction. The aim of this study is to investigate the utility of EMP in evaluating coronary intermediate lesions. Participants included 49 patients with coronary intermediate lesions and 24 subjects with normal coronary arteries. Among these subjects, 28 patients accepted fractional flow reserve (FFR). Results showed that level of EMP was significantly higher in the intermediate lesion group. No correlation was found between EMP and FFR value, suggesting that circulating EMP is a systemic marker rather than a focal one.
Acknowledgements
Special thanks to Chung-Kuao Chou (Yuan’s General Hospital, Taiwan) and Xuguo Zhou (University of Kentucky) for their corrections and opinions in manuscript writing.
Declaration of interest
This project was supported by the Leading Academic Discipline Project of Beijing Education Bureau and Beijing Natural Sciences Foundation (7122200), Grants 2011CB503900 from “973” National S&T Major Project, Grants 81170101, 81370235 from the National Natural Science Foundation of China, and Grants 7122106 from the Natural Science Foundation of Beijing, China.