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Abstract
Context: The evaluation of the liver condition, based on serum enzymatic activity and biopsies, is insufficient. Therefore, it is a priority to find a correlation between circulating RNAs and liver damage.
Methods: Publications were retrieved by the search terms “circulating RNA AND liver”.
Results: Although differences exist between studies, a profile of RNAs that repeatedly appeared as indicators of liver damage was identified.
Discussion: We highlight those circulating RNAs useful to diagnostic, and discuss the transport mechanisms.
Conclusion: Several studies have proven that circulating RNAs are useful to establish a diagnostic and a prognosis of liver diseases.
Declaration of interest
The authors disclose no conflict of interest. The work was supported by Grants PS09/00526 & PI12-01604 to JMFP from Spanish Ministry MICINN integrated in the National plan I + D + I and cofunded by the ISCIII-Subdirección General de Evaluación and the European Fund for Regional Development (Feder); and GV PI2012-45 to JMFP by Basque Government. Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd) is funded by the Spanish ISCIII-MICINN.
Supplementary material available online Supplementary Table 1