Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women

Stefan KluzekOxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, ;Arthritis Research UK Sports, Exercise and Osteoarthritis Centre of Excellence, University of Oxford, Oxford, UK, Correspondence[email protected]

Anne-Christine Bay-JensenNordic Bioscience Biomarkers and Research, Herlev, Denmark,

Andrew JudgeOxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, ;MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK,

Morten A. KarsdalNordic Bioscience Biomarkers and Research, Herlev, Denmark,

Matthew ShorthoseMedical Sciences Division, University of Oxford, Oxford, UK, and

Tim SpectorDepartment of Twin Research and Genetic Epidemiology, King’s College London, London, UK

Deborah HartDepartment of Twin Research and Genetic Epidemiology, King’s College London, London, UK

Julia L. NewtonArthritis Research UK Sports, Exercise and Osteoarthritis Centre of Excellence, University of Oxford, Oxford, UK,

Nigel K. ArdenOxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, ;Arthritis Research UK Sports, Exercise and Osteoarthritis Centre of Excellence, University of Oxford, Oxford, UK, ;MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK,

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Abstract

Context and objective: We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women.

Materials and methods: Five hundred and ninety-three women with no baseline KOA underwent 5-year knee radiographs over 20-years and were asked about knee pain a month before each assessment. A repeated measures logistic regression model was used where the outcomes were recorded at 5, 10, 15 and 20-years follow-up.

Results: The highest quartile of sCOMP was associated with increased risk of RKOA with overall OR of 1.97 (95% CI: 1.33–2.91) over 20 years when compared with the lowest sCOMP quartile. The association with painful KOA was similar and also independent, but only when the fourth and third sCOMP quartiles were compared.

Discussion and conclusion: This study demonstrates that sCOMP levels are predictive of subsequent structural changes and incidence of painful KOA, independently of age and BMI.

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Acknowledgements

The Synarc laboratory in Lyon for assisting in the sCOMP measurement. The study was partly funded by the TreatOA program.

Declaration of interest

ACBJ and MK are full-time employees and shareholders of Nordic Bioscience, a privately owned biotech company involved in biomarker development and validation. However, they have no commercial interest in the specific biomarker described in this paper sCOMP.

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women

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Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women

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