Abstract
This study investigates the status of vitamins in nervous and non-nervous tissues of methylmercury chloride (MMC)-intoxicated mice as well as during their exogenous application either alone or in combination with monothiols. The mice were intoxicated with MMC at a daily dose of 1 mg kg −1 for 7 days and thereafter for another 7 days treated separately with vitamin B complex, vitamin E, glutathione and N-acety-DL-homocysteine thiolactone (either alone or in combination). One group was kept without toxicant during this period. One intoxicated group was sacrificed on the eighth day, the rest were sacrificed on the fifteenth day. The study shows a significant decrease of vitamin B1, B2, B6, and E in all the tissues (except riboflavin in kidney and liver of the withdrawal group which show significant increase) during intoxication and a significant recovery (in many cases to control level) during therapy.