Abstract
Background: The purpose of this work was to determine the accuracy of Proton Resonance Frequency (PRF) thermometry during MR-guided Focused Ultrasound (MRgFUS) ablation on explanted Thiel embalmed human and animal liver, fresh animal liver, and compared to gel phantom. Material and methods: PRF thermometry during MRgFUS was conducted using a 1.5T MRI system. The phantom and the organs were sonicated with the following energies:300J, 600J, 1000J and 1400J. The temperature increase which was measured using PRF thermometry during sonication was compared to actual temperature rise in the same conditions measured by fibre optic thermocouple. Results: Sonication of fresh animal liver showed temperature differences varying between 0.27°C and 0.40°C, whereas the phantom results showed temperature differences from 0.23°C to 0.40°C. For the Thiel embalmed organs, the temperature difference varied from 1.17 °C to 3.13°C for the ovine liver, and from 1.3°C to 3.10°C for the human liver. Conclusion: The temperature differences measured in the fresh liver were small and similar to those found for the gel phantom. However, the temperature differences calculated for the Thiel embalmed organs were higher compared to the fresh organ. This indicates that the PRF-based temperature calibration of the Focused Ultrasound machine for Thiel embalmed tissue is necessary.
Acknowledgements
The authors are thankful for financial assistance provided by the project FUSIMO (“Patient specific modelling and simulation of focused ultrasound in moving organs”) funded under the EU's Seventh Framework Programme for Research and Technological Development. We would also like to thank Dr. Roos Eisma from CAHID project and Mrs. Helen McLeod for providing us with Thiel embalmed human tissue.
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.