A close correlation between plasma and serum levels of brain-derived neurotrophic factor (BDNF) in healthy volunteers

Reiji Yoshimura Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, JapanCorrespondence[email protected]

Atsuko Sugita-Ikenouchi Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan

Hikaru Hori Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan

Wakako Umene-Nakano Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan

Kenji Hayashi Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan

Asuka Katsuki Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan

Nobuhisa Ueda Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan

Jun Nakamura Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan

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Abstract

Objective. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic family found in both the central and the peripheral nervous system. Blood BDNF levels are considered as a state marker for depression. Methods. We investigated serum and plasma levels of BDNF levels in 103 healthy volunteers (M/F: 39/64, age: 37±12 years) using ELISA methods. Results and Conclusions. Serum BDNF levels were 14-fold higher than plasma BDNF levels, and a close relationship was found between serum and plasma BDNF levels.

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Acknowledgements

This work was supported by grants-in-aid for National Center of Neurology and Psychiatry in Japan.

Disclosure of interests

None

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A close correlation between plasma and serum levels of brain-derived neurotrophic factor (BDNF) in healthy volunteers

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A close correlation between plasma and serum levels of brain-derived neurotrophic factor (BDNF) in healthy volunteers

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