The long term effects of childhood sexual abuse: rationale for and experience of pharmacotherapy with nefazodone

Abstract

Studies estimate that 1 in 6 women and 1 in 10 men experience childhood sexual abuse (CSA). Whilst ill-health is not an inevitable consequence, approximately 20% of victims go on to have serious long-term pathology. This is reflected in an excess incidence of CSA survivors in problem populations, be they medical, forensic or psychiatric. Four groups of research studies suggest that PTSD-related mechanisms might be a major mediating factor in the development of symptoms: 1. There is high incidence of PTSD following sexual trauma; 2. Psychometric studies show evidence of impaired limbic functions; 3. There is evidence of neuroendocrine disturbances similar to those seen in war veterans with PTSD; 4. MRI studies show evidence of hippocampal atrophy. There is a growing database of studies showing that drugs that act as seroionergic modulators are effective in the treatment of PTSD. Drugs such as nefazodone which block 5HT₂ receptors and inhibit the uptake of serotonin may be of particular value. Studies suggest that trauma-related issues are not always addressed in patients with a history of abuse. Given the problems posed, there is a need to review their treatment in the light of emergent knowledge. Further research is needed to validate these findings.

Key Words:

• sexual abuse
• nefazodone
• neuroendocrine
• PTSD
• SSRI
• serotonin