Does age affect the efficacy and safety of GreenLight HPS^™ laser photoselective vaporization prostatectomy?

Abstract

Background: To evaluate the efficacy and safety of GreenLight HPS^™ (High Performance System) laser photoselective vaporization prostatectomy (PVP) for the treatment of benign prostatic hyperplasia (BPH) in patients of different age groups. Methods: 164 consecutive patients were stratified into two groups: age <70 (group I, n = 93) and age ≥70 (group II, n = 71) years. Transurethral PVP was performed using a GreenLight HPS™ side-firing laser system. Voiding parameters were measured preoperatively and at 1 and 4 weeks and 3, 6, 12, 18, 24 and 36 months postoperatively. Results: Among the preoperative parameters evaluated, there were significant differences (p < 0.05) in prostate volume (I: 58.7; II: 73.6 mL) and serum prostate-specific antigen (I: 1.9; II: 2.9 ng/mL), while American Urological Association Symptom Score (AUASS), Quality of Life (QoL), maximum flow rate (Qmax), Sexual Health Inventory for Men (SHIM) and post void residual (PVR) were similar (p > 0.05) between groups. No significant differences in laser utilization, energy usage and operating time were noted. Clinical outcomes (AUASS, QoL, Qmax, PVR) showed immediate and stable improvement from baseline (p < 0.05) within each group, but no significant differences between the two groups were observed during the follow-up period. The incidence of adverse events was low and similar in both groups. Conclusions: The results suggest that age has little effect on the efficacy and safety of GreenLight HPS™ laser PVP.

Keywords::

• Age
• benign prostatic hyperplasia
• clinical outcomes
• lithium triborate (LBO) laser
• photoselective vaporization of the prostate

Acknowledgements

The authors are thankful for the contributions from Glenn M. Sulley, RN, Colleen F. Davis, MA, DeAnna J. Kuykendall, MA, Raquel Carranco, MA and Maria E. Gonzalez, MA.

Declaration of interest: Carson Wong, MD is a consultant for American Medical Systems, Inc. This work was supported in part by the Endourological Society and Cook Urological Corporation.