Chronic mucocutaneous candidiasis and systemic lupus erythematosus: a new variant of chronic mucocutaneous candidiasis?

Abstract

Chronic mucocutaneous candidiasis (CMC) is characterized by susceptibility to Candida infection of skin, nails, and mucous membranes. Autoimmune endocrinopathies are common in CMC patients, but there are no reports of the involvement of systemic autoimmune disorders. We present here the first case of this kind of association in a patient with an autosomal dominant variant of CMC. The individual had had this disorder since childhood and systemic lupus erythematosus with secondary antiphospholipid syndrome, as well as renal, articular and hepatic manifestations without thymoma.

Keywords:

• Candida
• chronic mucocutaneous candidiasis
• autoimmune diseases
• systemic lupus erythematosus
• autosomal dominant inheritance

Acknowledgements

This work was partially supported by Fundação de Amparo a Pesquisa de São Paulo (FAPESP) grant number, 02/00024-2 and 99/07399-7.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

This paper was first published online on Early Online on 10 October 2011.