Abstract
The duration of the incubation of invasive aspergillosis (IA) remains unknown. The objective of this investigation was to estimate the time interval between aplasia onset and that of IA symptoms in acute myeloid leukemia (AML) patients. A single-centre prospective survey (2004–2009) included all patients with AML and probable/proven IA. Parametric survival models were fitted to the distribution of the time intervals between aplasia onset and IA. Overall, 53 patients had IA after aplasia, with the median observed time interval between the two being 15 days. Based on log-normal distribution, the median estimated IA incubation period was 14.6 days (95% CI; 12.8–16.5 days).
Acknowledgements
We thank Anne Thiebaut, Anne-Lise Bienvenu, Giovanna Cannas, Xavier Thomas, Frank-Emmanuel Nicolini, Frédérique De Monbrison and Marie-Antoinette Piens for their collaboration. Manuscript editing by Ovid Da Silva is acknowledged.
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and the writing of the paper.
This paper was first published online on Early Online on 7 June 2012.