Symptoms, health behavior and understanding of menopause therapy in women with premature menopause

Abstract

Objective To explore symptoms, understanding of menopausal therapies, medication use and health-related behavior in women with and without premature menopause.

Methods Cross-sectional, questionnaire-based study involving a community-based sample of 77 women in Australia: 23 premenopausal, 25 with premature ovarian failure (POF) and 29 with medically induced premature menopause (MIPM).

Results The median (interquartile range) age of each group was: premenopausal = 29 (13) years, POF = 36 (8.0) years and MIPM = 38 (4.0) years (p < 0.001). The reported frequency of menopausal symptoms differed across the groups for difficulty sleeping (premenopausal = 26%, POF = 44%, MIPM = 69%, p = 0.01), some depression symptoms (premenopausal = 4.4–22%, POF = 20–25%, MIPM = 38–59%, p < 0.05), hot flushes (premenopausal = 4.4%, POF = 28%, MIPM = 59%, p < 0.001), sweating at night (premenopausal = 4.4%, POF = 20%, MIPM = 52%, p < 0.001) and loss of interest in sex (premenopausal = 17%, POF = 52%, MIPM = 54%, p = 0.02). More women with premature menopause than premenopausal women reported taking prescription medication (premenopausal = 52%, POF = 92%, MIPM = 86%, p = 0.002), perceived that hormone therapy (HT) was associated with increased breast cancer risk (premenopausal = 43%, POF = 56%, MIPM = 79%, p = 0.03) and that HT prevented fractures (premenopausal = 13%, POF = 56%, MIPM = 39%, p = 0.01). Most women reported not knowing risks/benefits of bioidentical hormone therapy (premenopausal = 86%, POF = 56%, MIPM = 75%, p = 0.06). Regarding health-related behavior around prevention and screening, varying rates of bone densitometry (premenopausal = 4.4%, POF = 64%, MIPM = 59%, p < 0.001), blood glucose testing (premenopausal = 39%, POF = 67%, MIPM = 57%, p = 0.16) and cholesterol testing (premenopausal = 22%, POF = 71%, MIPM = 54%, p = 0.003) were reported.

Conclusions Differences in understanding of menopausal therapies and health-related behavior exist among women with premature menopause of differing etiology and premenopausal women. While perceived understanding of HT was greater than other therapies, targeted education is needed regarding specific risks/benefits of menopausal therapies and regarding preventive health screening after premature menopause.

Key words::

• PREMATURE MENOPAUSE
• MENOPAUSE THERAPIES
• HORMONE REPLACEMENT
• HEALTH BEHAVIOR
• SCREENING
• OSTEOPOROSIS
• CARDIOVASCULAR DISEASE
• CAM

ACKNOWLEDGEMENTS

Dr Amanda Deeks contributed to study design and implementation. Mr Sanjeeva Ranasinha provided assistance and advice with statistical analysis. Parts of this manuscript were presented at the 15th International and 14th European Congress of Endocrinology, 5–9 May 2012, Florence, Italy.

Conflict of interest Dr A. Vincent is a member of the Editorial Board for Climacteric. The authors have no other conflicts of interest to declare. The authors alone are responsible for the content and writing of this paper.

Source of funding Professor Teede is a National Health and Medical Research Council Fellow. Ms Gibson-Helm is supported by an Australian Postgraduate Award.