Oxidative stress in trisomy 21: A possible role in cataractogenesis

Abstract

Previous studies have suggested that free radicals and related species play a role in lens damage. The molecules involved may include proteins, lipids and DNA⁸. Focal cortical changes and cortical liquefaction have been reported in patients with Down's syndrome over the age of 15 years⁹.

There is evidence supporting the hypothesis that trisomy 21 patients have an increase in free radical reactions and lipoperoxidation susceptibility. This could be due to an increase in the H₂O₂ generation catalysed by CuZn SOD although the activity of other gene products coded for on chromosome 21 cannot be excluded.

Thiobarbituric acid reactive products were measured in human erythrocytes of nine DS patients and nine age-matched controls. There was a significant increase in the first group (21.0 ± 2.3 nmol MDA/g Hb vs 16.4 ± 2.9 nmol MDA/g Hb; p ≤ 0.01). In plasma, however, TBA products and antioxidant levels (ascorbic acid, tocopherol and uric acid) were not significantly different. Further studies should be carried out, namely through the use of more specific and sensitive methods, to assess the possible association between oxidative stress and cortical lens damage in DS patients.

Key Words:

• trisomy 21
• lipoperoxidation
• malondialdehyde
• oxidants
• antioxidants
• lens
• cataracts