In vivo immunomodulatory activities of the aqueous extract of bonduc nut Caesalpinia bonducella seeds

Abstract

This study evaluated the in vivo immunomodulatory activities of the aqueous extract of Caesalpinia bonducella Fleming (Caesalpiniaceae) seeds. C. bonducella is a plant widely used in the traditional medicinal systems of India. In the present investigation, the aqueous extract of C. bonducella seeds was tested for its effect on cell mediated and humoral components of the immune system in rats. Administration of C. bonducella seed extract produced an increase of 93.03 ± 4 mean hemagglutinating antibody (HA) titer and a change of 0.56 ± 0.058 mm in delayed type hypersensitivity (DTH) as compared to control at a dose of 400 mg/kg body weight. Thus, the results of this study indicate that C. bonducella extract could be a promising immunostimulatory agent.

Keywords::

• Caesalpinia bonducella
• cell mediated immunity
• humoral immunity

Acknowledgements

The authors are grateful to the Head of the Department of Botany and Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar, Madhya Pradesh, India, for providing laboratory facilities, and Madhya Pradesh Science and Technology, Bhopal, Madhya Pradesh, India, for providing financial assistance.

Declaration of interest: The authors report no conflicts of interest.