A trimethoxyellagic acid glucuronide from Conocarpus erectus leaves: Isolation, characterization and assay of antioxidant capacity

Abstract

The new trimethoxy-ellagic glycoside, 3,3′,4′-tri-O-methylellagic acid 4-O-β-glucupyranuronide and twelve known phenolics were isolated from the leaves of Conocarpus erectus L. (Combretaceae). Structures of all compounds were determined on the basis of spectroscopic methods and chemical degradation. The new compound, together with four of the isolated known constituents and the plant extract itself, showed potent inhibitory effect against reactive oxygen species attack on salicylic acid in a dose-dependent manner adopting xanthine/hypoxanthine oxidase assay.

Keywords::

• Conocarpus erectus L.
• 3,3′,4′-tri-O-methylellagic acid 4-O-β glucupyranuronide
• antioxidant

Acknowledgements

The author is grateful to Professor Dr. R.W. Owen, Division of Toxicology and Cancer Risk Factor, German Cancer Research Center (DKFZ), Heidelberg, Germany, for hosting the antioxidant activity at his lab.

Declaration of interest

The Author declares that there is no conflicts of interest to disclose. The author would like to express her utmost gratitude to the Egyptian government for its generous post doctor and scientific mission.