Abstract
Chemical constituents as well as cytotoxic and insecticidal activity of the crude methanol extract from the leaves of Phyllanthus reticulatus Poir. (Euphorbiaceae) were investigated. (5R*,6R*)-4,6-Dimethoxycarbonyl-5-[2′,3′,4′-trihydroxy-6′-(methoxycarbonyl) phenyl]-5,6-dihydro-2H-pyran-2-one (1) along with 3,4,3′-tri-O-methylellagic acid, and methyl gallate were isolated from the dichloromethane extract. Determination of their structures was based on spectroscopic analysis. Compound 1 possessed a very weak insecticidal activity against Spodoptera frugiperda (Sf9) with an IC50 value of 27.27 μg/mL.
Acknowledgements
The authors are grateful to the Graduate School of Silpakorn University and Silpakorn University Research and Development Institute (SURDI) for financial support.
Declaration of interest
The authors are grateful to the Faculty of Pharmacy for research facilities, and the Scientific and Technological Research Equipment Center for EIMS and NMR experiments.