Isolation and Hypoglycemic Activity of Arborans A and B, Glycans of Aloe arborescens var. natalensis Leaves

Hiroshi Hikino Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan

Michiko Takahashi Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan

Miki Murakami Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan

Chohachikonno Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan

Yoshiaki Mirin Research Laboratory, Koshiro and CO., 1-10-13 Ina, Minoo, Osaka, Japan

Masami Karikura Research Laboratory, Koshiro and CO., 1-10-13 Ina, Minoo, Osaka, Japan

Teruaki Hayashi Research Laboratory, Koshiro and CO., 1-10-13 Ina, Minoo, Osaka, Japan

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Abstract

Polysaccharide fractions of the leaves of a number of Aloe species significantly reduced blood sugar level in mice. Activity-directed fractionation of the polysaccharide fraction from Aloe arborescens Mill. var. natalensis (Wood, et Ev.) Bgr. leaves yielded two glycans, arborans A and B, which elicited marked hypoglycemic effects in normal and alloxan-induced hyperglycemic mice.

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Isolation and Hypoglycemic Activity of Arborans A and B, Glycans of Aloe arborescens var. natalensis Leaves

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Isolation and Hypoglycemic Activity of Arborans A and B, Glycans of Aloe arborescens var. natalensis Leaves

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