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Abstract
The hypotensive effect of the herb Crataegus oxyacantha was investigated in vivo using normal anaesthetised rats. An aqueous extract of Crataegus oxyacantha leaves was found to produce a significant decrease in the systolic, diastolic and mean blood pressure, but no effect was noticed on heart rate. The hypotensive effect was dose dependent and reversible with a median effective dose of 31 mg/kg. It seems that the hypotensive effect of Crataegus oxyacantha is not mediated via adrenergic, muscarinic or histaminergic receptors.