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Abstract
Extracts of Lawsonia inermis were studied for abortifacient activity. The methanolic extract was most effective in inducing abortion in mice, rats and guinea pig. The effect apparently is dosage dependent. This confirms its use in ethnomedicine for procurement of abortion in humans in some parts of Nigeria. No mechanism of action was detected in isolated tissue experiments. The results of the whole animal experiments support the methanolic extract's effectiveness as an abortant due to its maternal and fetal toxic effects.