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Abstract
The effect of the aqueous extracts of leaves and stems of Rosmarinus officinalis, Pimpinella anisun, Matricaria chamomilla, Artemisia vulgaris. Origanum vulgare, Lupinus albus and Olea europaea, were studied on the Picrotoxin-induced seizures in mice. In this study, the effect on the mortality rate, onset of convulsion, and γ-aminobutyric acid (GABA) content, were monitored. Extracts of Rosmarinus officinalis, Pimpinella anisum, Matricaria chamomilla and Artemisia vulgaris were found to delay the onset of picrotoxin-induced seizures and to decrease the mortality rate. On the other hand, extracts of Origanum vulgare, Lupinus albus and Olea europaea were found to have no effect on the onset of convulsions or on the mortality rate.