Effects of Milk Latex of Fig (Ficus carica) on ³H-Benzo(a)pyrene Binding to Rat Liver Microsomal Protein

Abstract

The effects of milk latex on ³H-Benzo(a)pyrene [³H-B(a)P] binding to rat liver microsomal protein were investigated. Milk latex produced dose-dependent inhibition of ³H-B(a)P binding. However, milk latex activity decreased following centrifugation to 2 layers (upper and lower layers). Furthermore, milk latex activity decreased significantly after extraction with chloroform or ether and when heated at 100°C. The milk latex activity may be due in part to a protein fraction(s) as the important contributor for inhibiting ³H-B(a)P binding to rat liver microsomal protein.