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Abstract
A saponin rich fraction was isolated from the fruit pulp of Sapindus trifoliatus L. It was tested for postcoital antifertility effects in female albino rats on different days of pregnancy. When injected intraperitioneally (20 mg/rat) on days 6–9 or on days 1–14, it impaired fertility in 7/10 and 10/10 animals, respectively. However, no significant fertility impairment occurred when this dose was administered on Days 1–3, 1–7 or 4–7. This fraction also appeared to be antiestrogenic when tested with 1 μg 170-estradiol.