Anti-diarrhoeal Efficacy of Some Burmese Indigenous Drug Formulations in Experimental Diarrhoeal Test Models

Abstract

Five indigenous drug formulations (IDFs) claimed to have anti-diarrhoeal action were studied with experimental test models,- namely in vitro rabbit ileal preparations as well as in vivo test models on mice and rats for gastrointestinal motility and castor oil-induced purgation. Drugs IDF-16 and IDF-35b were found to possess significant anti-diarrhoeal activity, with experimental anti-diarrhoeal indices of 77% and 82% respectively. Since their raw ingredients are available locally and cheaply, both drugs are appropriate for clinical evaluation.