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Abstract
Context: Aristolochia tagala Cham. (syn: Aristolochia acuminata Lam.) (Aristolochiaceae), known as Nallayishwari in Telugu, has been of interest to researchers because of its traditional uses for treating rheumatic pains and fever.
Objective: The anti-inflammatory activity of the petroleum ether, ethyl acetate, and ethanol extracts of A. tagala roots were investigated for the first time.
Materials and Methods: In vivo and in vitro anti-inflammatory effects were investigated employing the carrageenan-induced hind paw edema in rats and the macrophage cell line RAW264.7 stimulated with proinflammatory stimuli (lipopolysaccharide interferon γ or the calcium ionophore A23187) to determine PGE2 or LTB4 release, respectively.
Results: All the extracts exhibited anti-inflammatory effects which were found to be significant (p < 0.001) at 200 and 400 mg/kg, p.o, in rats tested and the ethyl acetate extract inhibited the induction of PGE2 with IC50 = 39.1 mg mL−1 and LTB4 with IC50 = 29.5 mg mL−1.
Discussion and conclusion: These findings demonstrate that the A. tagala roots have excellent anti-inflammatory activity and validate the traditional indications of this plant in its origin country.
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Acknowledgements
We are very grateful to Dr. M. Venkaiah, Professor, Department of Botany, College of Science and Technology, Andhra University, Vishakapatnam, AP, India for his valuable information on identification of plant material.
Declaration of interest
The authors report no declaration of the interest.