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Abstract
The effects of the aqueous extract of Glaucium arabicum on smooth muscles of rabbit and guinea pig were tested in vitro using isolated segments of intestine, trachea, and aorta. The aqueous extract of G. arabicum inhibits the spontaneous movement of the rabbit jejunum and the contractions of rabbit jejunum and guinea pig ileum induced by acetylcholine stimulation. Also, the aqueous extract inhibits the contractions of rabbit trachealis muscle induced by acetylcholine stimulation and the contractions of guinea pig trachealis muscle induced by histamine stimulation. This inhibition is dose-dependent and is reversible. However, the aqueous extract does not inhibit the contractions of rabbit and guinea pig aortic rings induced by norepinephrine stimulation. These data suggest that this plant has antispasmodic, anticholinergic and antihistaminic effects.