Abstract
Magnoflorine and aristolochic acid-1 were isolated from Aristolochia bracteata and their pharmacologic actions studied. Magnoflorine decreased arterial blood pressure in rabbits and induced hypothermia in mice. Both compounds induced contractions in the isolated pregnant rat uterus and stimulated the isolated guinea pig ileum. Experiments with standard agents in these models suggest action on muscarinic and serotonergic systems, cither directly or indirectly.
Ripe fruits of Aristolochia bracteata were collected in the Khartoum area (Sudan). The fruits were