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Abstract
The Effects Of An Aqueous Extract Of Peganum Harmala Seeds On The Smooth Muscles Of Rabbit and Guinea Pig Were Tested In Vitro Using Isolated Segments Of Intestine, Trachea and Aorta. The Extract Inhibited The Spontaneous Movement Of The Rabbit Jejunum and Guinea Pig Ileum and The Contractions Of Rabbit Jejunum and Guinea Pig Ileum Induced By 10−4M Acetylcholine Stimulation. The Extract Also Inhibited The Contractions Of Rabbit Tracheal Smooth Muscle Induced By 10−4M Acetylcholine Stimulation and The Contractions Of Guinea Pig Tracheal Smooth Muscle Induced By 10−4M Histamine Stimulation. Furthermore, The Extract Inhibited The Contractions Of Rabbit and Guinea Pig Aortae Induced By 10−4M Norepinephrine Stimulation. These Inhibitions Were Concentration-Dependent and Reversible. These Data Suggest That This Seed Extract Has Antispasmodic, Anticholinergic, Antihistaminic and Antiadrenergic Effects.