![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
Aqueous extracts of Myristica fragnans (Nut-meg) are used as a diarrhoea1 remedy in the traditional system of medicine. In the present study, alcohol and ether extracts of nut-meg (dried fruits and flowers) have been found anti-secretory in rabbit and guinea pig ileal loops against E. coli heat labile (LT) and heat stable (ST) enterotoxins. Among the hexane, chloroform, ethyl acetate. and water-soluble fractions prepared from the alcohol extract of nut-meg, the hexane-soluble fraction was found most active. In rabbit or guinea pig ileal loops, this fraction (300 mg/loop) inhibited LT (81.6%). ST (75%). and LT/ST (70.5%) toxin-induced secretory responses.