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Abstract
Aqueous garlic (Allium sativum L.) extract and the polar and thiosulfinate fractions were evaluated for their effects on the immune function of human peripheral blood mononuclear cells in vitro. The thiosulfinate fraction was found to contain diallyl thiosulfinate (allicin), allyl methyl and methyl allyl thiosulfinates and tranj-l-propenyl allyl thiosulfinate. The aqueous extract and the polar fraction increased interleukin-1 production, and the thiosulfinate fraction enhanced natural killer cell activity. The aqueous garlic extract, polar and thiosulfinate fractions increased interlenkin-2 production. Neither the agueour nor the fractions stimulated lymphocyte blastogenesis.