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Abstract
The aqueous-methanolic extract of Artemisis scoparia (0.01 mg/ml) completely blocked serotonin-induced contractions in rat uterus while it had no effect on the agonist response of serotonin in guinea-pig ileum. At higher concentrations (0.1–0.3 mg/ml) it caused concentration-dependent inhibition of spontaneous movements of rat uterus as well as acetylcholine or serotonin-induced ileal contractions. These data indicate that the plant contains specific antiserotonergic (5HT2) blocker and general spasmolytic constituents).