TNF-alpha inhibitors in Systemic Lupus Erythematosus. A case report and a systematic literature review

Marta MoscaDepartment of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, PisaItalyCorrespondence[email protected]

Chiara TaniDepartment of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, PisaItaly

Maria Elena FilicePathology Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy

Linda CarliDepartment of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, PisaItaly

Andrea Delle SedieRheumatology Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy

Sabrina VagnaniDepartment of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, PisaItaly

Alessandra Della RossaRheumatology Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy

Chiara BaldiniDepartment of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, PisaItaly

Stefano BombardieriDepartment of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, PisaItaly

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Abstract

Joint involvement is a common manifestation of systemic lupus erythematosus (SLE) and is described as a non-erosive mild synovitis. However some SLE patients may present a more severe joint involvement requiring aggressive therapy. We describe the case of a SLE patient with a severe arthritis unresponsive to methotrexate, successfully treated with anti-TNF-alpha drug as induction therapy and we report the results of a systematic literature review on the use of TNF-alpha inhibitors in SLE.

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TNF-alpha inhibitors in Systemic Lupus Erythematosus. A case report and a systematic literature review

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TNF-alpha inhibitors in Systemic Lupus Erythematosus. A case report and a systematic literature review

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