Coexistence of familial Mediterranean fever and rheumatoid arthritis

Kiyoshi MigitaDepartment of Rheumatology, Clinical Research Center, NHO National Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8652, JapanCorrespondence[email protected]

Seigo AbiruDepartment of Hepatology, NHO National Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8652, Japan

Osamu SasakiDepartment of Nephrology, NHO National Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8652, Japan

Taiichiro MiyashitaDepartment of Rheumatology, Clinical Research Center, NHO National Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8652, Japan

Yasumori IzumiDepartment of Rheumatology, Clinical Research Center, NHO National Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8652, Japan

Ayako NishinoDepartment of Rheumatology, Clinical Research Center, NHO National Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8652, Japan

Yuka JiuchiDepartment of Rheumatology, Clinical Research Center, NHO National Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8652, Japan

Atsushi KawakamiDepartment of Rheumatology, Nagasaki University Hospital, Nagasaki, Japan

Michio YasunamiInstitute of Tropical Medicine, Nagasaki University, Nagasaki, Japan

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Abstract

Familial Mediterranean fever (FMF) is an autoinflammatory disorder characterized by recurrent febrile polyserositis and arthritis. Although accompanying seronegative spondyloarthropathy has been reported in FMF, coexistence with rheumatoid arthritis (RA) is very rare. This case report describes a Japanese female RA patient who presented with periodic fever. Genetic analysis revealed compound heterozygous mutations in exon 2 and 3 of the MEFV gene (E148Q/G304R/P369S/R408Q). The patient was successfully treated with colchicine with 3-year follow-up.

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Coexistence of familial Mediterranean fever and rheumatoid arthritis

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Coexistence of familial Mediterranean fever and rheumatoid arthritis

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