Acknowledgments
We thank Dr. Eisuke Inoue and all of the members of the Institute of Rheumatology, Tokyo Women’s Medical University for the successful management of the IORRA cohort. We also thank Prof. M. Matsumoto, Prof. M. Nakamura and the other members of the Department of Orthopedic Surgery, Keio University School of Medicine for their support. This work was supported in part by grants-in-aid for scientific research from the Japan Society for the Promotion of Science, the Nakatomi Foundation, the Japan Orthopedics and Traumatology Foundation, Inc. No. 277, and the Japan Osteoporosis Foundation to KO, and from the Japan Osteoporosis Society to TF.
Conflict of interest
Katsunori Ikari has received honoraria for speaking and/or unrestricted research grants from AbbVie, Inc., Asahi Kasei Pharma Corp., Astellas Pharma Inc., Bristol-Myers Squibb Co., Chugai Pharmaceutical Co., Eisai Co., Ltd. Hisamitsu Pharmaceutical Co. Inc., Janssen Pharmaceutical K.K., Kaken Pharmaceutical Co. Ltd., Mitsubishi Tanabe Pharma Co., Santen Pharmaceutical Co., Ltd., Taisho Toyama Pharmaceutical Co. Ltd. and Takeda Pharmaceutical Co., Ltd. Hisashi Yamanaka has received research grants from Abbott, AbbVie, Asahikasei, Astellas, AstraZeneca, Bristol-Myers Squib, Chugai, Daiichi Sankyo, Eisai, GlaxoSmithKline, Janssen, Mitsubishi Tanabe, MSD, Nippon Kayaku, Pfizer, Santen, Taishotoyama, Takeda, and Teijin; has received consulting fees from Abbott, AbbVie, Astellas, AstraZeneca, Bristol-Myers Squib, Chugai, Daiichi Sankyo, Eisai, Mitsubishi Tanabe, Nippon Kayaku, Pfizer, Takeda, and Teijin; and has participated in speakers bureaus for Abbott, AbbVie, Astellas, Bristol-Myers Squib, Chugai, Eisai, Mitsubishi Tanabe, Pfizer, Takeda, and Teijin. Shigeki Momohara has received honoraria for speaking and/or unrestricted research grants from AbbVie, Inc., Asahi Kasei Pharma Corp., Bristol-Myers Squibb Co., Chugai Pharmaceutical Co., Daiichi Sankyo Co., Ltd., Eisai Co., Ltd., Mitsubishi Tanabe Pharma Co., Nakashima Medical Co., Ltd., Santen Pharmaceutical Co., Ltd., Taisho Toyama Pharmaceutical Co. Ltd. and Takeda Pharmaceutical Co., Ltd. The sponsors were not involved in the study design; collection, analysis, and interpretation of the data; writing of the paper; and/or decision to submit for publication.