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Original Article

Computerized analysis of antimicrobial drugs interactions in biological systems using an IBM-PC microcomputer

Pages 307-316 | Received 22 Oct 1985, Published online: 12 Jul 2009
 

Abstract

We have developed a computer program to analyse the individual and combined effects of two treatments applied concurrently to a biological system. Analysis is done in regard to: (1) level of significance selected for the statistical test (two-sided Student's t test); (2) number of data available; (3) expected combined effect resulting from addition (computed by the program); (4) experimental hypothesis tested (synergism or antagonism). The main program gives access to eight options: (1) input of new data; (2) input of data from file; (3) addition or modification to data in memory; (4) display on monitor the results from analysis or the contents of a data file; (S) analysis with another level of significance; (6) printout; (7) kinetics of interaction; (8) end of program. The program is designed to work with an IBM-PC, Epson MX/FX 80/100 printer and Roland DXY 800 plotter. Sample runs are given.

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