Antioxidant effect of functionalized alkyl-organotellurides: a study in vitro

Abstract

We evaluated the in vitro antioxidant effect of alkyl-organotellurides A–D on lipid peroxidation and protein carbonylation in rat liver homogenates. The thiol oxidase and thiol peroxidase-like activities of compounds were investigated. δ-Aminolevulinic acid dehydratase (δ-ALA-D) activity was determined in rat liver homogenates. Compounds A–D protected against lipid peroxidation induced by Fe²⁺/EDTA and sodium nitroprusside (SNP). According to the confidence limits of the IC₅₀ values of compounds A–D, the IC₅₀ values for organotellurides followed the order: C (0.30 µM) ≤ B (0.40 µM) < D (0.68 µM) < A (2.90 µM), for Fe²⁺/EDTA, and B (0.21 µM) ≤ C (0.33 µM) ≤ D (0.43 µM) < A (1.21 µM) for SNP-induced lipid peroxidation. Compounds A–D reduced protein carbonyl content to control levels. The results demonstrated an inverse correlation between thiol oxidase and δ-ALA-D activities. This study supports an antioxidant effect of organotellurides A–D on rat liver.

Keywords::

• Functionalized alkyl-organotellurides
• antioxidant
• tellurium
• liver lipid peroxidation