Sulfonamide derivatives of thiazolidin-4-ones with anticonvulsant activity against two seizure models: synthesis and pharmacological evaluation

Abstract

A series of 4-thiazolidinones bearing a sulfonamide group (4a–w) were prepared by cyclizing various 5-bromo-2-methoxy-N’-[(1E)-arylmethylene/arylethylidene]benzenesulfonohydrazides. All the compounds were characterized by IR, ¹H NMR, and elemental analysis. The compounds were tested for their anticonvulsant activity utilizing MES and scPTZ animal models. The majority of the compounds exhibited significant activity against both animal models; however, compounds 4c, 4m, and 4o displayed promising activity and could be considered as leads for further investigations.

Keywords::

• thiazolidin-4-ones
• sulfonamides
• anticonvulsant activity

Acknowledgments

The authors express their gratitude to Jamia Hamdard, New Delhi (India) for providing the necessary facility to carry out this research work.

Declaration of interest

One of the authors (M.F.A.) is thankful to the University Grants Commission (UGC), New Delhi for awarding a Junior Research Fellowship (JRF).